One point that Charles Murray makes effectively in Human Diversity is that human migration necessarily creates different genetic patterns.
If we start with a tribe of 200 people, and 100 of them break off and move to a new location, those 100 cannot possibly take with them a representative sample of the gene pool of the whole tribe. There are many possible genetic combinations, but by arithmetic the new tribe can only take 100 combinations with them.
Here are some thoughts I have about that;
1. An assumption that Murray makes, which I believe is accurate, is that there is not much re-mixing. The old tribe and the new tribe cross-breed very little, if at all. In prehistoric days, the physical separation made cross-breeding unlikely. Also mutual tribal suspicion.
2. My guess is that some human colonies survived, and some didn’t. The ones that survived preserved their genetic tendencies and cultural traits.
3. Surviving colonies tend to stay put. If the colony really thrives and its population increases, then it will send out more migrant colonies.
4. My guess is that when long-distance communication and transportation was primitive, failing colonies tended to just fail. As technology improved, failing colonies would be more inclined to migrate, because they have better knowledge of where life might be better.
5. Of all of the colonies that humans ever created, only a relatively few were successful. When your genome is used to speculate about your ancestry, it is linking you back to one or more of the successful colonies.
6. If only a small proportion of colonies were successful, then of all of the viable combinations of genes, only a few will be present. Evolution will not have selected with extreme rigor. Yes, some of the colonies failed because of weak genes. But others failed because of bad luck or bad culture. And not very many combinations of genes were tried.
7. I think that this picture reinforces my skepticism about polygenic scores ever being able to explain much of the observed variation in heritable traits. We will observe some combinations of genes with great frequency, making additional sampling from those populations redundant from a statistical perspective. My intuition continues to be that we are now or soon will be at the point of greatly diminishing returns to increased sample size.
8. It is not just prehistoric migration that follows the colony model. Consider David Hackett-Fisher’s Albion’s Seed. Consider the Bosnian community in St. Louis, the Hmong community in Minneapolis-St. Paul, etc.
9. The more that a migrating colony marries endogamously and brings strong cultural beliefs when it migrates to a larger society, the longer it can persist without without dissolving into that society. Consider Orthodox Jews.
10. What will emerge from the migration process is populations with differences in both genetic makeup and cultural practices. Most of these differences are random, as opposed to selective. This will make it difficult to pin down the extent to which differences in outcomes across populations have genetic causes.